%PDF-1.4 %âãÏÓ 1 0 obj <> endobj 2 0 obj <>stream 2021-08-17T12:38:06 Adobe InDesign 15.0 (Windows) 2021-08-23T09:42:20+02:00 2021-08-23T09:42:20+02:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Aging;High-dimensional mediators;Iterative sure independence screening;Mediation analysis; False application/pdf https://doi.org/10.1186/s12859-021-04322-1 BioMed Central BMC Bioinformatics, https://doi.org/10.1186/s12859-021-04322-1 Aging High-dimensional mediators Iterative sure independence screening Mediation analysis Estimation of total mediation effect for high-dimensional omics mediators Tianzhong Yang Jingbo Niu Han Chen Peng Wei 10.1186/s12859-021-04322-1 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s12859-021-04322-1 10.1186/s12859-021-04322-1 1471-2105 journal BMC Bioinformatics The Author(s) 2010-04-23 true 10.1186/s12859-021-04322-1 noindex springer.com springerlink.com uuid:909e4ea1-73e6-4987-b500-20dd0cacdd51 uuid:f7192d76-8766-4078-b2b2-76c9da2fe7c7 default 1 converted uuid:909e4ea1-73e6-4987-b500-20dd0cacdd51 converted to PDF/A-2b pdfToolbox 2021-08-17T12:45:35Z 2 B Peng Wei http://orcid.org/0000-0001-7758-6116 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text